NCLEX Pharm Focus
Does Pharmacology cause you much anxiety? According to the National Council State Board of Nursing (NCSBN), Pharmacological and Parental Therapy represent 12-18% of the RN NCLEX exam while 11-17% represent a portion of the PN NCLEX exam. With this in mind, familiarizing yourself with the commonly asked medications is an important part of your NCLEX preparation.

Amikacin sulfate

Brand Name(s):

  • Amikin

Pharmacologic Class:

  • Aminoglycoside
  • Serious infections caused by sensitive strains of Pseudomonas aeruginosa, Escherichia coli, Proteus, Klebsiella, or Staphylococcus
  • Uncomplicated UTI caused by organisms not susceptible to less toxic drugs


  • Inhibits protein synthesis by binding directly to the 30S ribosomal subunit; bactericidal.
Adverse Reactions:
  • CNS: neuromuscular blockade
  • EENT: ototoxicity
  • GU: azotemia, nephrotoxicity, increase in urinary excretion of casts
  • Musculoskeletal: arthralgia
  • Respiratory: apnea
Nursing Considerations:
  • Be aware that I.V. loop diuretics such as furosemide may increase ototoxicity.
  • Obtain specimen for culture and sensitivity tests before giving first dose. Begin therapy while awaiting results.
  • Obtain blood for peak level 1 hour after I.M. injection and 30 minutes to 1 hour after I.V. infusion ends; for trough levels, draw blood just before next dose.
  • Monitor renal function, including urine output, specific gravity, urinalysis, BUN and creatinine levels, and creatinine clearance. Report any evidence of declining renal function.
  • Watch for signs and symptoms of superinfection (especially of upper respiratory tract), such as continued fever, chills, and increased pulse rate.
  • Don’t confuse amikacin with anakinra.

Patient Teaching:

  • Instruct patient to promptly report adverse reactions to prescriber.
  • Encourage patient to maintain adequate fluid intake.
Phone: 1-650-303-5488
Office: 90 So. Spruce Ave. Suite P
South San Francisco, CA 94080

D&D Nursing Educators, Inc., 90 So. Spruce Ave. Suite P South San Francisco, CA 94080

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